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On stroke risk in type 2 diabetes : focus on glycemic control, insulin resistance, obesity and recovery
(2023-08-14)
Background: People with type 2 diabetes (T2D) have an increased risk of cardiovascular disease. In this thesis the focus is on stroke with different aspects of aims, e.g. the risk of stroke in people with T2D, the role of ...
Being young with a cancer experience : health-related quality of life with special focus on independence and sexuality
(2014-04-29)
The increased survival rates for persons with a cancer experience from childhood imply that health care professionals working in different areas of the health care sector will encounter young persons with a cancer experience. ...
On the detection and management of urinary bladder carcinoma
(2008-11-07)
Aims: To describe the diagnosis and clinical course of an unselected population-based cohort of patients with newly diagnosed transitional cell carcinoma of the urinary bladder. To assess if random bladder biopsies and the ...
Adjuvant tamoxifen in breast cancer : clinical and preclinical studies on the prediction value of estrogen receptor
(2010-09-17)
Breast cancer (BC) exhibits great heterogeneity at histophatological, clinical and molecular levels. However, the different clinical outcomes in patients with seemingly similar breast cancer have led scientists to search ...
Streptococcus pyogenes infections and toxic shock syndrome : molecular epidemiology and immunotherapy
(2006-03-08)
Streptococcus pyogenes, also known as group A streptococcus (GAS), is an important human pathogen causing a wide variety of diseases. One of the most severe diseases is streptococcal toxic shock syndrome (STSS), which is ...
Analytical strategies for identifying relevant phenotypes in microarray data
(2007-11-28)
With microarray technology, the transcription thousands of genes can be determined simultaneously. The large number of genes, often assessed in a relatively small number of samples, presents a challenge. The risk of making ...
Health outcomes of women with breast cancer
(2014-12-17)
The overall survival of breast cancer patients has increased quite remarkably in the past decades in the developed countries due to substantial improvements in diagnosis and treatment. As a consequence, the proportion of ...
von Willebrand disease in women : heavy menstrual bleeding and obstetrical bleeding
(2018-09-25)
Von Willebrand disease is the most common inherited bleeding disorder worldwide with a prevalence, reaching 1% of general population. vWD is equally distributed between genders. However, vWD-affected females experience ...
Analysis and characterization of chemo- and radiation therapy sensitizing strategies in tumours with focus on effects of phenothiazines on DNA damage response signalling
(2015-09-22)
Cancer is, despite rapid progress in development of new targeted therapies, still mainly
treated with surgery, chemotherapy and/or radiation therapy. The last two mentioned
conventional therapies often meet general ...
Dissection of HIV-1 Env-specific B cell responses in nonhuman primates
(2012-10-25)
Vaccine-induced protection is generally mediated by long-lived antigen-specific B cell responses. Most licensed vaccines target pathogens that display relatively low variability, but for highly variable pathogens, such as ...