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Improved diagnosis and management of sepsis and bloodstream infection
(2022-11-08)
Sepsis is a severe organ dysfunction triggered by infections, and a leading cause of hospitalization and death. Concurrent bloodstream infection (BSI) is common and around one third of sepsis patients have positive blood ...
Modulation of the HPA axis alters the sensitivity of the cochlea to acoustic trauma
(2006-10-27)
The hypothalamic pituitary adrenal axis (HPA axis) regulates nearly all neuroendocrine responses of the body. An active HPA axis is crucial to maintaining homeostasis. An altered reactivity of the HPA axis can affect several ...
Neurorestorative strategies involving neurogenesis, neuronal precursors and stem cells in animal models of Parkinson's disease
(2009-10-08)
The general aims of the thesis is to provide evidence for neurogenesis in the adult substantia nigra pars compacta (SNpc), where the dopamine-producing neurons lost in Parkinson's disease (PD) reside; to optimize methods ...
On antidepressant effects of running and SSRI : focus on hippocampus and striatal dopamine pathways
(2007-05-25)
Considering the heterogeneous character of depression, it seems likely
that many brain regions are involved mediating the diverse symptoms of
depression. For example, the mesolimbic DA system has a central function
for ...
Personality, stress and risk of Parkinson's disease
(2020-05-08)
The objective of this thesis was to investigate the relationship of personality and stress with subsequent risk of Parkinson’s disease (PD). In Study I, we conducted a population-based cohort study using questionnaire data ...
Genetics in experimental traumatic brain injury
(2012-11-08)
Traumatic brain injury (TBI) is the leading cause of death and disability in the young population in the industrialized world. It comprises a heterogeneous group of brain pathologies where head trauma initiates a series ...
In vivo bioluminescence imaging in preclinical trials of genetic vaccines
(2017-12-15)
DNA immunization is a rapidly developing vaccine platform for infectious diseases, cancer and allergies. The efficiency of DNA vaccination is largely determined by the efficiency of delivery and subsequent expression of ...
Guillain-Barré syndrome : disability, quality of life, illness experiences and use of healthcare
(2006-10-27)
Aim: The overall aim of this thesis was to provide a comprehensive description of how individuals may be affected by GuillainBarré syndrome (GBS), in terms of on body function, activity, and participation as well as on ...