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Targeting ALK and WIP1 : neuroblastoma precision medicine under development
(2022-10-26)
Neuroblastoma is the childhood solid tumor accountable for the largest number of deaths, calling for improved treatment. Some genetic alterations are considered crucial in driving initiation and progression of neuroblastoma. ...
Hormonal influences on cholesterol and bile acid metabolism : focusing on involvement of PCSK9
(2018-05-07)
Elevated plasma LDL-C is today considered a causative factor for the development of atherosclerosis. Increased plasma LDL-C levels are mainly due to reduced numbers of functional LDL receptors (LDLRs) in the liver. PCSK9 ...
Small-molecule inhibitors of the receptor tyrosine kinases : promising tools for targeted cancer therapies
(2014-08-11)
Chemotherapeutic and cytotoxic drugs are widely used in the treatment of cancer. In spite of the improvements in the life quality of patients, their effectiveness is compromised by several disadvantages. This represents a ...
Role of cholesterol metabolism in hepatic steatosis and glucose tolerance
(2019-04-12)
The liver is the central organ for lipid, lipoprotein and glucose homeostasis, thus hepatic metabolic disturbances can predispose individuals to develop cardiometabolic disorders (CMD) such as atherosclerotic cardiovascular ...