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Genetic studies of acute lymphoblastic leukemia
(2007-09-21)
Acute lymphoblastic leukemia (ALL) is the most common pediatric malignancy, comprising approximately 25% of all childhood cancers. A huge improvement in outcome of children with ALL during the last 20 years has resulted ...
Role of cholesterol metabolism in hepatic steatosis and glucose tolerance
(2019-04-12)
The liver is the central organ for lipid, lipoprotein and glucose homeostasis, thus hepatic metabolic disturbances can predispose individuals to develop cardiometabolic disorders (CMD) such as atherosclerotic cardiovascular ...
Pharmacological targeting of nonsense mutant TP53 and PTEN in cancer
(2023-09-15)
The TP53 tumor suppressor gene encodes p53 and is inactivated by mutations in
around half of all human tumors. Approximately 11% of TP53 mutations are
nonsense mutations, resulting in the premature termination of translation ...