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Understanding the role and regulation of Polη for damage-induced cohesion
(2021-10-28)
In response to DSBs, de novo sister chromatid cohesion can be established after DNA replication in Saccharomyces cerevisiae. The damage-induced cohesion is formed close to the break and genome-wide on undamaged chromosomes. ...
Urocortins in the zebrafish brain and redox regulation of embryonic development through glutaredoxins
(2012-03-29)
The cellular redox state is a central regulator of embryonic development. Redox homeostasis and thiol redox signaling are modulated through glutaredoxins (Grxs), glutathione dependent thiol-disulfide oxidoreductases. Grxs ...
Structure and function in c-Myc and Grx4 : two key proteins involved in transcriptional activation and oxidative stress
(2006-11-24)
The proto-oncogene c-myc is critical for growth and development and deregulation of c-myc expression affects the initiation and expansion of a wide range of human cancers, many of them aggressive. cMyc is a multi-domain ...
Biochemical properties of human glutaredoxins
(2004-05-07)
Glutaredoxins (Grxs) are highly conserved thiol-disulfide oxidoreductases that utilize electrons from the tripeptide glutathione (GSH) to catalyze thiol-disulfide exchange reactions. Bacteria, yeast and plants contain ...