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Analysis of antibodies to cartilage oligomeric matrix protein in rheumatoid arthritis and in mouse models
(2021-10-13)
Rheumatoid arthritis (RA), a common autoimmune disease, affects 0.5-1% of the world’s population. It is not only an important health problem but also a socioeconomic problem considering that it can lead to joint destruction ...
Targeting MTHFD1 and MTHFD2 as cancer treatment
(2023-09-18)
One-carbon (1C) metabolism provides building blocks for nucleotide synthesis and
therefore plays a central role in DNA replication and repair. To sustain rapid proliferation,
cancer cells often upregulate their 1C ...
Unwrapping the role of WRAP53β in DNA damage response
(2016-04-29)
WRAP53β is a WD40 domain protein with multifaceted capabilities in several biological processes in different cellular compartments. This includes transportation of the Survival of motor neuron (SMN) complex, small Cajal ...
Molecular characterization of the cancer susceptibility protein wrap53β in Cajal body formation and DNA repair
(2013-11-04)
WRAP53β is a multifaceted protein involved in several biological processes including Cajal body maintenance, cancer cell survival and DNA damage repair. By directing factors to Cajal bodies and DNA double-strand breaks ...
Finding synergies for cancer treatment : new ways to modulate DNA damage repair by CX3CR1 and PFKFB3 inhibition
(2021-06-01)
The goal of targeted cancer therapy is to selectively kill cancer cells based on their molecular survival mechanisms. DNA repair is as a promising cancer target as many cancers have chronic replication stress and deficiencies ...
Molecular characterization of phenothiazines in experimental cancer therapy : new tricks of an old drug revealed
(2012-04-04)
Cancer is characterized by uncontrolled malignant proliferation of cells that eventually interfere with tissue/organ functions. Traditionally, cancer is treated with chemo- and/or radiotherapy when surgery is not an option. ...