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Unwrapping the role of WRAP53β in DNA damage response
(2016-04-29)
WRAP53β is a WD40 domain protein with multifaceted capabilities in several biological processes in different cellular compartments. This includes transportation of the Survival of motor neuron (SMN) complex, small Cajal ...
Drug treatment in children with focus on off-label drug use
(2010-08-06)
There is a lack of paediatric documentation concerning efficacy and
safety of many drugs, which contribute to drug use outside the terms of the product license (off-label). In the present thesis, four studies (I-IV), using ...
Associations between obesity, periodontal inflammation, subgingival microflora and salivary flow rate
(2015-10-02)
Obesity is a large health problem and is associated with increased risk of diabetes type II, cardiovascular disease as well as implicated in a wide range of gastrointestinal disorders such as Crohn’s disease and subclinical ...
In vivo functions of mammalian glutaredoxin 2
(2008-08-29)
Oxygen is essential for all respirating life forms. However, the use of molecular oxygen as terminal electron acceptor of the respiratory electron chain leads to the generation of reactive oxygen species (ROS) as product ...
Immune response and tumour cell detection in lymph nodes of head and neck cancer
(2018-10-18)
Many patients with head and neck squamous cell carcinoma present with regional spread to the cervical lymph nodes. Lymph nodes metastases are today the most important factor influencing both the treatment and outcome for ...
The role of the RNA-binding protein Wig-1 in post-transcriptional regulation of gene expression
(2014-10-17)
The p53 transcription factor is activated by cellular stress. This triggers transcriptional activation of a number of p53 target genes, leading to responses such as cell cycle arrest and/or induction of apoptosis. Wig-1 ...
Tracking selective attention in a musical cocktail
(2021-08-18)
The cocktail party effect refers to mankind’s ability to focus attention on a single sound within noisy or complex auditory environments, in order to extract the most behaviourally-relevant information present. To investigate ...
Studies of immune response in human tuberculosis
(2013-11-21)
TB (tuberculosis), caused by Mycobacterium tuberculosis (Mtb), continues to be a world-leading killer and a serious global health problem primarily affecting poor people in many developing countries. The difficult situation ...
Local immune responses in tuberculosis : cytolytic effector functions at the site of mycobacterium tuberculosis infection
(2013-03-22)
Despite recent advances in tuberculosis (TB) research, shortage of knowledge still exists that limits the host-pathogen interactions in human TB. Cell-mediated immunity has been shown to confer protection in TB, although ...
Prognostic factors in colorectal cancer : studies of thymidylate synthase expression, mismatch repair protein expression, tumor budding and t-cell infiltration
(2019-09-26)
Colorectal cancer (CRC) is a major health problem in the Western world. CRC is treatable with surgery and often curable when the disease is diagnosed at an early stage. With improved surgery and adjuvant chemotherapy ...