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On the cholinergic c-bouton
(2004-04-28)
The cholinergic C-bouton is a large nerve terminal type exclusively contacting motoneuron cell somata and proximal dendrites. C-boutons are characterized by subsurface cisterns found beneath the postsynaptic membrane, which ...
Improved surgical treatment of oesophageal cancer
(2021-08-20)
Oesophageal cancer is the 7thmost common cancer globally and the 5-year survival is poor (below 20%). Curative treatment usually involves surgical resection of the tumour (oesophagectomy), with or without neoadjuvant ...
Calcium signaling and network activity : mathematical modeling and molecular mechanisms
(2017-05-17)
The calcium (Ca2+) ion is a versatile second messenger present in all cells. It is involved in such diverse processes as cell division, differentiation, vesicle transport and muscle contraction. Its widespread applicability ...
Microsomal prostaglandin E synthase 1 and microsomal glutathione transferase 1 : inhibition and mechanism
(2014-05-16)
The Membrane-Associated Proteins in Eicosanoid and Glutathione Metabolism (MAPEG) is
a family of six membrane bound proteins with different biological functions. MAPEG
superfamily members enable and catalyze reactions ...
Hypothyroidism caused by a mutant thyroid hormone receptor alpha1 : consequences for development and physiology
(2008-01-11)
Lack of sufficient thyroid hormone during pregnancy and early postnatal
development results in profound mental retardation and motor deficits
whereas altered thyroid status in the adult is associated with disturbed
metabolic ...
A battle between host and pathogen : the innate immune response and enterovirus evasion strategies
(2014-09-18)
Infections with Coxsackieviruses are common and in most cases the infection is asymptomatic and efficiently cleared. On rare occasions, however, an infection can lead to severe diseases including myocarditis, hepatitis and ...
Characterization of malignant pleural mesothelioma : possibilities for an individualized therapeutic arsenal
(2014-01-28)
Less than 50% of malignant mesothelioma patients respond to standard chemotherapy treatment and there is a great need to identify these patients, and find their best treatment options. The aim of this thesis was to increase ...
Psychomotor disturbances in bipolar disorder : investigations using structural and functional neuroimaging
(2013-09-11)
Psychomotor disturbances in bipolar disorder are an expression of alterations in volition, cognition, emotion and motor control. While psychomotor disturbances remain a classic hallmark of severe mood disorders, there is ...