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Cell lineage analysis in humans
(2021-07-29)
Delineating a cell’s history, where it came from and what has happened to it, can provide clues as to how tissues and organs are formed and function in the healthy state and in disease. The gold standard for tracing the ...
Studies on the mechanism of regulation of bile acid synthesis in humans with some aspects on genetic factors
(2005-10-28)
In the present investigation we studied human bile acid synthesis and its regulation both in vivo and in vitro and also evaluated a possible influence of polymorphisms in the CYP7A1 and CYP8B1 genes on bile acid synthesis ...
Memory B-cell function and antibody profiles in malaria : their role in protection against disease in infancy
(2017-02-02)
Malaria infection is of huge public health importance in developing countries, including Uganda. Antibody immunity assumes a paramount part in the disease control however there’s a great need to study components of antibody ...
Intravenous induction of anaesthesia in children : aspects on propofol and etomidate
(2016-04-29)
Propofol is today the most commonly used drug for induction of anaesthesia and for short-term sedation. However, one specific problem is that intravenous injection of propofol often results in quite severe injection pain, ...
Studies on cholesterol and bile acid metabolism in Chinese cholesterol gallstone patients
(2010-03-26)
Liver and intestine are important organs for the metabolism of cholesterol and bile acids in the body. Dysfunction in cholesterol and bile acid metabolism may lead to diseases such as cholesterol gallstone (GS) disease and ...
Chemokines and chemokine receptors during viral infections in man
(2007-11-08)
Chemokines and chemokine receptors are critical mediators of cell migration during immune surveillance, inflammation and development. The generation of antibody responses depends on B and T cell collaboration within germinal ...
Factors influencing splanchnic microcirculation in animal models of endotoxaemia
(2011-04-20)
Even though severe sepsis and septic shock therapy has improved in recent years, mortality remains high (22-50%). Disturbances in splanchnic organ homeostasis and increases in gut permeability have long been presumed to ...
Molecular subclassification, stem cell markers and growth regulatory pathways in gliomas
(2015-05-11)
Glioblastoma is the most common and aggressive primary brain tumor in adults. Median
survival is no more than 15 months, even with combined treatment regimens. The lack of
accurate pre-clinical model systems has limited ...
Alzheimer disease : subcellular Aβ mechanisms and treatment strategies
(2023-02-01)
The amyloid β-peptide (Aβ) is the key molecule in the pathogenesis of Alzheimer disease (AD), but the mechanisms of its toxicity are still largely unknown. This thesis includes studies aimed at studying Aβ induced mechanisms ...
Tall stature : morbidity, mortality and treatment outcomes
(2016-01-15)
Tall stature is usually constitutional. In some cases excessive growth is caused by early puberty and in others by growth disorders such as Marfan syndrome or pituitary gigantism. Some individuals experience a substantial ...