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Attention-deficit/hyperactivity disorder and educational outcomes : etiology, treatment effects, and occupational outcomes
(2021-08-12)
Attention-Deficit/Hyperactivity Disorder is one of the most prevalent childhood-onset developmental disorders, and is associated with a wide range of problematic functional outcomes such as low educational attainment (EA), ...
Hypothyroidism caused by a mutant thyroid hormone receptor alpha1 : consequences for development and physiology
(2008-01-11)
Lack of sufficient thyroid hormone during pregnancy and early postnatal
development results in profound mental retardation and motor deficits
whereas altered thyroid status in the adult is associated with disturbed
metabolic ...
Atrial fibrillation and lifestyle factors with focus on physical activity and alcohol consumption
(2017-02-06)
The overall aim of this thesis was to investigate how modifiable lifestyle factors, with a focus on alcohol consumption and physical activity, influence the risk of atrial fibrillation (AF). The thesis is based on data ...
Mechanisms of thrombosis and restenosis after vascular injury
(2005-04-22)
Atherosclerosis is the underlying cause of about 50% of all deaths in the western world. Peripheral vascular disease commonly affects the arteries supplying the leg and is mostly caused by atherosclerosis. When medical ...
MicroRNA expression and function in virus-associated human cancers
(2013-12-13)
microRNAs (miRNAs) are small non-coding RNAs that play important roles in gene regulation. It is now clear that miRNAs participate in tumor development and progression. Despite many studies have reported specific miRNA ...
Nutrition in advanced cancer care : a clinical perspective
(2023-02-16)
Adequate nutrition is an essential part in all stages of cancer care. By optimizing the nutrition care the benefits include increased tolerance to treatment as well as decreased mortality. Understanding how aspects of ...
Following the white rabbit : release and regulation of HMGB1 in inflammation
(2019-02-21)
Dysregulated inflammatory responses are characterized by excessive release of endogenous pro-inflammatory molecules, danger-associated molecular patterns (DAMPs). A prototypical DAMP, High Mobility Group Box 1 protein ...
Functional analysis of long non-coding RNAs in cancer
(2017-11-24)
For years the functional role of noncoding RNAs was greatly underestimated. Whole genome RNA sequencing projects that unraveled pervasive transcription emitting from large parts of the human genome changed those perspectives ...
Molecular mechanisms of imatinib resistance in gastrointestinal stromal tumor with focus on microRNAs
(2014-12-16)
Gastrointestinal stromal tumor (GIST) is mainly initialized by mutations in receptor tyrosine kinase genes KIT or PDGFRA. The development of imatinib, a small molecule inhibitor that targets these tyrosine kinase receptors, ...
T cells in patients with B-cell chronic lymphocytic leukemia (B-CLL) and multiple myeloma (MM) : an immunological study
(2007-02-16)
There are several lines of evidence that T cells in patients with
Multiple Myeloma (MM) and B-cell Chronic Lymphocytic Leukemia (B-CLL) are
phenotypically aberrant. The overall aim of this thesis was to study T
cells ...