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Translational studies of syndecan-1 as angiogenesis inhibitor : from basic research to clinical applications
(2021-05-03)
Malignant mesothelioma (MM) is a highly aggressive primary tumor of the pleura, associated with poor prognosis. MM is mainly related to exposure to mineral fibers such as asbestos. The diagnosis of MM, despite multiple ...
Neurotransmitter phenotypes of neurons in the spinal cord and their functional role in the mouse locomotor network
(2010-03-03)
Walking is a special case of movement because it is rhythmic. An important area in current neuroscience research, is to better understand the different organizational levels (molecular, ion channels, neurotransmitters, ...
The effect of Gal alpha(1,3)gal glycopeptide-conjugates and human serum on HIV-1 infection and replication
(2012-10-23)
The first step in the entry of HIV-1 is the binding of the viral envelope glycoprotein (gp120) to the CD4 molecule expressed mainly on T helper cells. Upon binding, gp120 undergoes a series of conformational changes that ...
Regulation of NK cell activity : studies of DAP12-associated receptors in immune synapse formation and in responses to cytomegalovirus infection
(2006-10-27)
Natural killer (NK) cell effector functions are important for innate resistance against tumor cells and viral infections. NK cells display a broad range of inhibitory and activating receptors on the cell surface, which ...
Error, praise, action and trait : effects of feedback on cognitive performance and motivation
(2015-08-06)
This thesis investigates the role of trial-based feedback on cognitive performance and motivation. We conducted behavioural tests in the laboratory, functional magnetic resonance imaging (fMRI) to investigate brain activation, ...
Pharmacoepidemiology and health economics of adherence to pharmaceutical fracture prevention
(2020-04-06)
Background: Osteoporosis is a disease characterized by weak bone, affecting hundreds of millions of people worldwide, predominantly postmenopausal women. The main clinical consequence of the disease is bone fractures and ...
Lymphangiogenesis and lymphatic metastasis
(2005-11-18)
The major cause of cancer mortality is metastasis, which relies on the growth of blood vessels (haemangiogenesis) and lymphatic vessels (lymphangiogenesis). Whereas the field of haemangiogenesis has been relatively thoroughly ...
T cells in patients with B-cell chronic lymphocytic leukemia (B-CLL) and multiple myeloma (MM) : an immunological study
(2007-02-16)
There are several lines of evidence that T cells in patients with
Multiple Myeloma (MM) and B-cell Chronic Lymphocytic Leukemia (B-CLL) are
phenotypically aberrant. The overall aim of this thesis was to study T
cells ...