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Epidemiological aspects of sarcoidosis : risk factors and long-term consequences
(2021-01-27)
Sarcoidosis is a systemic inflammatory disease of unknown etiology in which granulomatous lesions form mostly in the lungs and the lymphatic system of patients. Although more than a century has passed since sarcoidosis was ...
Intrauterine immunology in allergy and infection
(2009-01-02)
Pregnancy is interesting from an immunological point of view. The maternal immune system has to tolerate the fetus and at the same time also protect against infection. The placenta is not a completely tight barrier: in ...
Studies on molecular properties and functional regulation of terminal leukotriene C4 synthases and cysteinyl-leukotriene receptor signalling in human endothelium
(2007-03-09)
The transformation of the unstable intermediate leukotriene (LT) A4 into
the glutathione conjugate LTC4, the parent compound of LTD4 and LTE4, is
catalysed by leukotriene C4 synthase (LTC4S) as well as microsomal
glutathione ...
T-cell specificity and regulation in atherosclerosis
(2015-12-14)
Cardiovascular disease is the main cause of death in the world. The underlying cause in most cases is atherosclerosis, a chronic inflammatory disease. Subendothelial retention of lipoproteins triggers monocyte-derived ...
Studies on coactosin-like protein interaction with 5-lipoxygenase
(2009-10-16)
Leukotrienes (LTs) are proinflammatory lipid mediators derived from polyunsaturated arachidonic acid, which is ester-bound at the sn-2 position of glycerol in cellular phospholipid bilayers. In LTs biosynthesis, 5-lipoxygenase ...
Leukotrienes and leukotriene receptors : potential roles in cardiovascular diseases
(2007-01-01)
Leukotrienes (LTs) are a family of lipid mediators that are involved in
host defense and inflammatory responses. They are synthesized from
arachidonic acid through the 5-lipoxygenase (5-LO) pathway, and are
divided into ...