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Telomerase in hematological and other malignancies : therapeutic implications
(2015-11-05)
The Telomere is a nucleoprotein complex consisting of TTAGGG repeated sequences covered by specialized binding proteins termed shelterins masking the end of linear chromosomes and thereby protecting the end of the chromosome ...
Wrist osteoarthritis : causes, treatment and outcome
(2022-08-12)
Wrist osteoarthritis is rare compared to osteoarthritis in the finger joints or thumb base and affects younger patients. Its etiology is heterogenous, and osteoarthritis may be caused by traumatic injuries, as well as by ...
Formation of the inhibitory KIR repertoire in human natural killer cells
(2012-01-23)
Natural killer (NK) cells are lymphocytes of the innate immune system that are able to secrete cytokines and detect virus infected and transformed cells. Contrary to T cells, NK cells recognize targets that lack expression ...
Host-microbe interactions in coxsackievirus infection : focus on innate immunity
(2010-05-28)
Coxsackievirus group B (CVB) is a common virus that usually causes only
mild symptoms in humans. However, occasionally these infections result in
severe diseases like meningitis, myocarditis and pancreatitis. In
addition, ...
The therapeutic potential of ex vivo expanded natural killer (NK) cells for immunotherapy of cancer
(2005-11-18)
Cell and gene therapy of cancers has received much attention in the past decade. A number of applications of cancer treatment have been developed and used. One of the recent applications is immunotherapy of tumours with ...
Natural killer cell inhibitory and activating receptors : regulatory role in effector functions against normal and tumor cells
(2007-11-09)
Natural killer (NK) cells can mediate effector functions as cytokine
production and degranulation dependent cytotoxicity against cells that
have become aberrant by mutagenesis or by infection. As part of the
innate ...