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Targeted therapy in chronic lymphocytic leukemia
(2020-04-28)
Chronic lymphocytic leukemia (CLL) is characterized by the accumulation of mature B lymphocytes in blood, bone marrow and lymphoid tissues. Historically, patients with TP53 aberration and with refractoriness to chemoimmunotherapy ...
Outcomes after surgical treatment of localized prostate cancer with focus on urinary incontinence and short term complications
(2015-02-09)
Background: Urinary incontinence is a significant long-term complication after radical
prostatectomy. The aim was to evaluate clinically significant definitions of urinary
incontinence and to investigate its potential ...
Ankle fracture surgery : clinical and epidemiological aspects
(2012-09-20)
Ankle fractures are one of the most common fractures treated in orthopaedic surgery today and the trend towards surgical treatment has increased over the past decades. The ankle is though a sensitive area for surgical ...
Clinical aspects on glucose-lowering therapies in type 2 diabetes
(2012-09-03)
Type 2 diabetes is a progressive disease with deterioration of glycaemic control over time in association with loss of endogenous insulin secretion. As a consequence of this, sulphonylureas (SU), which exert their mode of ...
Molecular mechanisms of imatinib resistance in gastrointestinal stromal tumor with focus on microRNAs
(2014-12-16)
Gastrointestinal stromal tumor (GIST) is mainly initialized by mutations in receptor tyrosine kinase genes KIT or PDGFRA. The development of imatinib, a small molecule inhibitor that targets these tyrosine kinase receptors, ...