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Follicular lymphoma : clinical and biological factors associated with response to therapy and overall prognosis
(2020-01-29)
Follicular lymphoma (FL) is a heterogeneous group of malignancies within the adaptive immune system. The clinical course is highly variable. Treatment includes different chemotherapy regimens as well as the anti-CD20 ...
The control of tuberculosis in the HIV era : improved tuberculosis diagnosis and development of vaccines for HIV prevention
(2014-04-16)
The HIV pandemic has reversed the gains in TB control and has thus contributed to an increase in TB morbidity and mortality, especially in low and middle-income countries. Improved TB diagnosis, active case finding as well ...
The role of FPR2/ALX in the vascular wall
(2015-09-24)
Cardiovascular diseases caused by atherosclerosis are a leading cause of mortality worldwide. Inflammation has been described as a key component in the development of atherosclerosis. Lipoxin A4 (LXA4) is a lipid mediator ...
Retinoids in the modulation of vascular inflammation
(2004-12-24)
Vascular disease is multifactorial. Smooth muscle cells, the major constituent of the normal vessel wall, play a pivotal role. The pathogenesis includes cellular differentiation, proliferation and inflammatory activation. ...
Antimicrobial and xenobiotic defence in the mammalian testis
(2012-05-24)
Different mechanisms exist in the mammalian testis to protect the germ cells from autoimmune attack, invading microbes, and xenobiotic induced toxicity, which would otherwise be deleterious to the preservation of fertility. ...
Characterizing cancer cell signaling at the protein level : from targeted to proteome and phosphoproteome‐wide analyses
(2017-09-11)
Proteins are the effectors of cellular functions and the constituting elements of cellular signaling cascades. The ability to analyze the abundances and the dynamics of proteins is central to dissect cellular signaling and ...
Signal integration between notch and hypoxia : insights into development and disease
(2007-01-26)
Oxygen is essentially required for aerobic metabolism in most eukaryotic
organisms. Therefore, it is striking that a number of tissues develop,
and are maintained at low oxygen (hypoxic) conditions in the body. For
instance, ...
Dopamine : a versatile player in development, regeneration and disease
(2018-03-06)
The dopamine neurotransmitter is present in all multicellular organisms. In the brain, the dopaminergic system orchestrates reward-motivation pathways and is involved in the control of voluntary movements and endocrine ...