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Signal integration between notch and hypoxia : insights into development and disease
(2007-01-26)
Oxygen is essentially required for aerobic metabolism in most eukaryotic
organisms. Therefore, it is striking that a number of tissues develop,
and are maintained at low oxygen (hypoxic) conditions in the body. For
instance, ...
Infections in patients with chronic kidney disease : patterns, outcomes and the role of vitamin D for future prevention
(2019-03-11)
Background: Chronic kidney disease (CKD) is increasingly recognized as a global public health problem. Patients with CKD are at high risk of infections. Frequent episodes of infections with greater use of antibiotics might ...
The dynamics of intra- and inter-organ communication during an acute kidney infection
(2022-01-27)
This thesis focuses on the roles of neuro-immune communication and infection-mediated coagulation during bacterial kidney infections. We demonstrate dynamic intra- and inter-organ host responses, where the outcome of an ...