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Exploring paths to youth suicide and sudden violent death : a multimethod case-control investigation
(2020-01-16)
Suicide and other forms of sudden violent death are the most common causes of death among young people worldwide. Both suicide and other forms of sudden violent death are more frequent among males than females. Risk factors, ...
Studies on ITK-SYK signaling pathways
(2013-05-24)
Chromosomal alterations are frequent causes of cancer. Until now, SYK is reported in two different chromosomal translocation events generating the ITK-SYK-fusion protein in a subset of peripheral T cell lymphomas and the ...
Proinflammatory and antigen-specific CD4+ T cells in rheumatoid arthritis
(2014-02-10)
Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune disease primarily affecting peripheral joints. In this thesis work we aimed to increase the knowledge about proinflammatory and antigen-specific CD4+ T cell ...
T cell subsets and disease mechanisms in inflammatory myopathies
(2014-08-12)
The idiopathic inflammatory myopathies (IIMs) are a heterogeneous group of chronic muscle disorders, typically displaying infiltrating T cells in skeletal muscle tissue and classified into polymyositis, dermatomyositis and ...
CD28null T cells in rheumatoid arthritis and inflammatory myopathies : cellular characterization and clinical relevance
(2007-11-16)
Rheumatoid arthritis and idiopathic inflammatory myopathies are rheumatic
disorders typically displaying infiltrating T cells in the affected
organs. Yet, despite much effort, the contribution and antigen
specificity ...