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Anatomical studies of the dopamine system in the hypothalamus and the pituitary gland
(2018-11-23)
The hypothalamus is a small, evolutionarily conserved brain region, necessary for our survival as individuals and as a species. It collects various sensory inputs, process them to maintain homeostasis and to overcome ...
Studies on ITK-SYK signaling pathways
(2013-05-24)
Chromosomal alterations are frequent causes of cancer. Until now, SYK is reported in two different chromosomal translocation events generating the ITK-SYK-fusion protein in a subset of peripheral T cell lymphomas and the ...
Microarray gene expression in immunological conditions
(2013-05-15)
The use of microarray techniques for gene expression analysis provides a global view of the transcriptional activity in a biological sample. In this thesis two conditions accompanied by disturbance in the immune system are ...
Respiratory mononuclear phagocytes during steady state and sarcoidosis
(2020-08-25)
Each day, our lungs inhale thousands of liters of air containing not only essential oxygen but also smoke particles, dust, allergens, and potentially dangerous pathogens. In order to tolerate harmless antigens and initiate ...
Origin and ontogeny of human lung macrophages
(2022-05-20)
The lung is a vital organ occupied by a large diversity of immune cells due to its close proximity with the external environment. This thesis focuses on a particular type of immune cell: the macrophage. The lungs are ...
Antimicrobial peptides and eicosanoids : roles and interactions in inflammation and host defense
(2017-04-05)
Antimicrobial peptides (AMPs) have a broad spectrum of activities and exert their functions by both direct killing of microbes through the interaction with the microbial membrane, and modulation of innate and adaptive ...