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Epidemiological and pathophysiological studies on diverticular disease in the colon
(2018-10-30)
Background: Diverticular disease of the colon is common and is associated with a high and increasing societal burden with great economical and human costs. Prevalence increases with age and with an overall aging population, ...
Role of estrogen receptor beta in epithelia lacking estrogen receptor alpha expression
(2008-04-18)
Estrogens influence the physiology of many organs by activation of the nuclear receptors ERalpha and ERbeta. The epithelium of ventral prostate, ovarian granulosa cells and lung, are ERalpha-negative but express high levels ...
ER subtype-specific regulation of estrogen signaling
(2011-11-24)
The estrogen receptor (ER) isoforms, ERα and ERβ, mediate the physiological functions of the female hormone estrogen. They share high degree of similarity but also show significant differences in many aspects, such as cell ...
Effect of selective estrogen receptor modulators (SERMs) on growth plate cartilage
(2010-05-14)
More than 300 years ago Dr. Stephen Hales drilled holes in the shaft of chicken bones and noted that as the animal grew, the distance between these holes remained constant. This led him to conclude that longitudinal bone ...
Estrogen actions in the growth plate cartilage
(2020-03-24)
Estrogens may influence bone growth locally or systemically via the estrogen receptors alpha (ERα), beta (ERβ) and G protein-coupled estrogen receptor 1 (GPER-1). In Paper I, our study showed that the treatment of ...
The use of antibiotic prophylaxis in implant dentistry : a microbiological and clinical perspective
(2017-11-24)
The current development of antibiotic resistance calls for prudent use of antibiotic prescription. Methods of investigating antibiotic overconsumption, include identifying areas of misuse or overuse, as well as implementing ...
Hormonal regulation of HES-1 in breast cancer cells
(2008-05-21)
Hairy and Enhancer of Split homolog 1 (HES-1) is a transcriptional repressor belonging to the basic helix-loop-helix family of proteins, and has been shown to have a pivotal role as a regulator of neurogenesis, myogenesis ...
Adjuvant tamoxifen and luteinizing hormone-releasing hormone agonists in premenopausal breast cancer : on long-term benefits and side effects in a randomised study
(2012-10-08)
Adjuvant endocrine therapy improves breast cancer survival, unconditional of other treatment. In premenopausal breast cancer, tamoxifen for 5 years is the standard treatment, with or without the addition of ovarian ablative ...
Novel human in vitro systems for studies of drug inducted hepatotoxicity
(2012-10-05)
Drug-induced liver injury (DILI) is a major human health concern, estimated to account for about half of all cases of acute liver failure in the general population. DILI also represents a significant problem in drug ...
Vascular related pathologies in cardiovascular disease and cancer
(2017-04-28)
Cardiovascular disease (CVD) and cancer are the leading causes of death worldwide. A damaged endothelium is one of the factors contributing towards these diseases. This thesis focused on understanding the implications of ...