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Novel human in vitro systems for studies of drug inducted hepatotoxicity
(2012-10-05)
Drug-induced liver injury (DILI) is a major human health concern, estimated to account for about half of all cases of acute liver failure in the general population. DILI also represents a significant problem in drug ...
Enzymatic activation of oxygen in the biosynthesis of polyketide antibiotics
(2009-09-04)
The electron structure of molecular oxygen (O2) is such that it cannot spontaneously react with organic molecules, a feature that protects organisms from oxidative stress. However, oxygenases can insert O2 in organic ...
Mechanistic insights into the biosynthesis of polyketide antibiotics
(2006-11-24)
Anthracyclines are a group of aromatic polyketide compounds with significant medical importance due to their antineoplastic properties. Doxorubicin and daunorubicin members of this family are among the two most commonly ...
Genetics of immunoglobulin a deficiency
(2018-03-19)
Immunoglobulin A deficiency (IgAD) is the most common primary immunodeficiency in Caucasian populations. It is defined as a serum IgA level below 0.07 g/L with normal IgM and IgG levels in an individual older than four ...