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The matter of white and gray matter in cognitive impairment
(2017-08-03)
Cognitive impairment spans from minor subjective cognitive impairment to disabling dementia. Many biomarkers have been developed to monitor different aspects of cognitive impairment. Magnetic resonance imaging is the most ...
Studies on alcoholic liver disease
(2006-11-17)
The overall aim of this thesis was to explore the impact of alcoholic cirrhosis in Sweden, and the relation between drinking patterns and beverage types and alcoholic cirrhosis, and to evaluate the possible role of ...
Impact of candidate genes on obesity and type 2 diabetes
(2011-03-11)
Obesity and type 2 diabetes (T2D) have strong genetic components. Identification of susceptibility genes in both diseases will give better knowledge of their pathomechanisms and future therapies. In this thesis, the candidate ...
Aspects on latency in HIV-1 infection
(2010-04-16)
The use of combination antiretroviral therapy (ART) has resulted in a substantial reduction in viremia, a rebound of CD4+ T-cells and increased survival for human immunodeficiency virus type 1 (HIV-1) infected individuals. ...
Molecular mechanisms underlying the oncogenic function of SS18 and SSX
(2008-01-04)
The SS18 and SSX genes were initially identified based on their
reoccurrence as fusion partners in synovial sarcoma. As a result of the
specific chromosomal translocation t(X:18), the SS18 gene from chromosome
18 becomes ...
A fibrinogen-binding protein from Staphylococcus epidermidis
(2001-11-09)
Staphylococcus epidermidis, a coagulase negative staphylococci (CoNS), is a major component of human flora. It is one of the leading pathogens of nosocomial infections, particularly associated with foreign body infections. ...
PET studies of the serotonin transporter in the human brain
(2006-10-27)
The serotonin (5-HT) system attracts considerable attention in research on the pathophysiology and drug treatment of neuropsychiatric disorders. The brain imaging technique Positron Emission Tomography (PET) allows for ...
Studies on the effects of thyroid hormone on cholesterol and lipoprotein metabolism
(2012-11-22)
Elevated plasma lipids, particularly cholesterol within low density lipoproteins, is an important risk factor for developing atherosclerosis which can cause angina pectoris, myocardial infarction, and stroke. Thyroid hormone ...
Immunity to malaria: importance of exposure and parasite polymorphism
(2014-04-25)
Malaria continues to carry an intolerable burden of disease and mortality, predominantly on children in Sub-Saharan Africa. An efficacious vaccine would be a powerful tool in the combat against malaria. Further understanding ...
Insights from comorbidity into multiple sclerosis aetiology and outcomes
(2014-10-31)
Aim: The overall aim of this research was to investigate the nature of the comorbidities in multiple sclerosis (MS) in four large population-based studies. The first study assessed whether the diagnosis underlying ...