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Psychiatric comorbidity in multiple sclerosis : biological and epidemiological aspects
(2017-01-23)
Multiple sclerosis (MS) is a chronic, neuroinflammatory disease and one of the leading reasons for neurological disability among young people in the Western World. MS patients commonly experience neuropsychiatric symptoms ...
Psoriasis : studies of phenotype at onset and of associated cardiovascular morbidity
(2005-08-12)
Psoriasis is a complex inflammatory skin disorder, affecting 2-3% of the population in the western world. The etiology of psoriasis is not yet known. However it is likely that its pathogenesis involves interplay between ...
HIV-1 infection and loss of serological memory : the role of altered expression of B-cell chemokine receptors, timing of HAART and impaired antibody affinity maturation
(2008-12-26)
Currently, big efforts in HIV-1 research are devoted to the design of a
HIV-1 vaccine. However, no successful vaccine is yet available, also due
to the lack of basic knowledge in HIV-1 pathogenesis which is still
profound. ...
B-cell responses after pertussis vaccination
(2014-05-02)
Despite years of vaccination efforts, whooping cough, or pertussis, is not under control. Although immunization has greatly reduced the disease incidence, thousands of children die of whooping cough each year. Therefore, ...
Cervical intraepithelial neoplasia in migrant women living with HIV
(2018-10-19)
The aim of this thesis was to study high-grade cervical intraepithelial neoplasia (CIN) in women
living with HIV (WLWH) in Sweden compared with HIV-negative women (HNW) of the same
region of birth.
In Paper I ...
Identification of genes that regulate arthritis and IgE production in rat and human
(2005-08-08)
Multiple genome-wide scans have identified quantitative trait loci (QTLs) that influence inflammatory diseases on chromosome 4q42 in DA rats. Several of the QTLs overlap with the QTL designated Oia2 (Oil-induced arthritis-2), ...
Functional gastrointestinal disorders, development of symptoms over time, and self-care
(2011-10-07)
Background: Adults with Gastrointestinal (GI) symptoms such as abdominal pain, acid regurgitation, flatulence, diarrhea, constipation and nausea constitute a large part of the patient population in both primary and specialist ...
Characterization of malignant pleural mesothelioma : possibilities for an individualized therapeutic arsenal
(2014-01-28)
Less than 50% of malignant mesothelioma patients respond to standard chemotherapy treatment and there is a great need to identify these patients, and find their best treatment options. The aim of this thesis was to increase ...
Studies on the clinical pharmacology of antiretroviral agents
(2009-09-11)
This thesis begins with an account of the development of the antiretroviral treatment paradigm for HIV infection, focusing on the emergence of present day principles of antiretroviral therapy (e.g., how to rationally combine ...
Real-world studies on B-cell malignancies
(2020-11-18)
Randomized controlled trials remain the preferred way of evaluating new treatments. However, in studies on malignancies, trial data may not always be sufficient to address the requirements of health care providers and ...