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Mechanisms and regulation of the polyphosphate/factor XII-driven contact system in thrombosis and hemostasis
(2016-10-03)
Blood coagulation leading to fibrin formation is essential to prevent loss of blood
(hemostasis), but can also contribute to occlusion of vessels (thrombosis). Thrombosis causes
pulmonary embolism, myocardial infarction ...
Experimental Chagas disease
(2003-05-14)
The main focus of this thesis was to develop and utilise experimental models using the protozoan parasite Trypanosoma cruzi. We were especially interested in studying the activation of NK cells early after T. cruzi infection ...
A study on the E3 ligase TRIM21/Ro52
(2008-01-04)
Patients with the systemic autoimmune diseases Sjögren's syndrome (SS) and systemic lupus erythematosus (SLE), often have antibodies against the intracellular protein TRIM21/Ro52. Although the presence of anti-TRIM21/Ro52 ...
Crosstalk of human mesenchymal stromal cells with the cellular components of the immune system
(2013-08-20)
Using the potential of immune regulatory cell populations for cellular therapy constitutes an attractive tool to obliterate imbalances of immune responses in inflammatory disorders. In this context, adoptive transfer of ...
Strategies to optimize natural killer cell functions in the tumor microenvironment
(2023-10-13)
Immune cell-based therapies are currently changing the oncological treatment landscape worldwide. While genetically modified T cells have already been approved for clinical use in few hematological cancers, natural killer ...
Health care on equal terms for immigrants in Sweden
(2012-08-24)
Background: There is limited knowledge about immigrant patients’ lower self-reported health (SRH) in relation to acculturation and discrimination and about immigrant patients’, interpreters’ and GPs’ experiences, reflections, ...