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Experimental Chagas disease
(2003-05-14)
The main focus of this thesis was to develop and utilise experimental models using the protozoan parasite Trypanosoma cruzi. We were especially interested in studying the activation of NK cells early after T. cruzi infection ...
Studies on the reliability of biomarkers for alcohol use and abuse
(2013-01-10)
Alcohol is consumed by the vast majority of the population, but prolonged excessive drinking is associated with various negative health and social consequences. It is therefore important to identify individuals with at-risk ...
Estrogens and lymphoma growth
(2015-05-25)
Lymphomas are generally not considered as endocrine-associated cancers. Nevertheless, most lymphoid malignancies show a gender differencein incidence and prognosis, with males being more affected.The molecular mechanism ...
Molecular pathogenesis of refractory anemia with ring sideroblasts (RARS) : role of the mitochondrial iron transporter gene ABCB7
(2011-08-18)
Refractory anemia with ring sideroblasts (RARS) is characterized by anemia, erythroid apoptosis, and mitochondrial ferritin (FTMT) accumulation. Granulocyte-colony-stimulating factor (G-CSF) inhibits some of these features ...
Estrogen actions in the growth plate cartilage
(2020-03-24)
Estrogens may influence bone growth locally or systemically via the estrogen receptors alpha (ERα), beta (ERβ) and G protein-coupled estrogen receptor 1 (GPER-1). In Paper I, our study showed that the treatment of ...
Characterization of hippocampal slice cultures as model systems for neurodegenerative processes in Alzheimer's disease
(2005-11-04)
Alzheimer's disease (AD) is the most common cause of dementia and a
growing health care problem worldwide. The disease affects different
brain regions, including hippocampus, enthorhinal cortex, amygdala,
neocortex and ...
Angiostatic mechanisms of endogenous angiogenesis inhibitors
(2003-05-02)
Angiogenesis, the process of sprouting of new capillaries from the existing blood vessels, is essential for tumor growth and metastasis. Angiostatin was discovered as the first specific endogenous angiogenesis inhibitor ...
Population and single-cell analysis of human cardiogenesis reveals unique LGR5 ventricular progenitors in embryonic outflow tract
(2021-02-15)
The morphogenetic process of mammalian cardiac development is complex and highly regulated spatiotemporally by multipotent cardiac stem/progenitor cells (CPCs). Mouse studies have been informative for understanding mammalian ...
Genotype-phenotype relations in SF3B1 mutated myelodysplastic syndromes with ring sideroblasts
(2016-10-28)
Myelodysplastic syndrome with ring sideroblasts (MDS-RS) is a clonal hematopoietic stem cell disorder characterized by hyperplastic and ineffective erythropoiesis, ring sideroblasts in the bone marrow, and anemia. Heterozygous ...
Impact of cardiovascular and neuropsychiatric multimorbidity on older adults' health
(2019-04-17)
Multimorbidity, the presence of two or more chronic diseases in one person, is common in older people, and associates with a number of negative outcomes. In this thesis, we propose a methodology to assess and measure ...