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Development of novel PET radioligands for visualizing beta cell mass and amyloid plaques
(2016-08-19)
The aim of the thesis was twofold. The first aim was to radiolabel small molecules by using carbon-11 and fluorine-18 for visualising beta cell mass (BCM) in the pancreas by PET. Diabetes Mellitus (DM) is a chronic metabolic ...
Toll-like receptor-induced cytokine secretion by human monocytes in healthy donors and septic patients assessed at the single cell level
(2013-08-23)
Following the ligation of Toll-like receptors (TLRs) by bacterial-derived signature molecules, innate immune cells such as monocytes, macrophages and neutrophils initiate the inflammatory process by secreting chemokines ...
Behavioral changes and mechanisms : an experimental study on aging in rodents
(2011-11-25)
In paper I, we studied alterations in behavior with advancing age in female C57BL/6 mice (of Jackson origin). In parallel, growth and survival data were collected. In a protected environment the median survival age was 32 ...
Role of thioredoxin system in cell death caused by toxic compounds
(2014-02-17)
Thioredoxin systems, comprising Trx, TrxR and NADPH, are one of the major disulfide reductase systems, which is crucial in maintaining cellular redox balance in mammalian cells. TrxR is a selenoprotein with a Sec residue ...
Investigating novel roles of topoisomerase regulatory interactions in transcription
(2023-01-25)
Drugs targeting DNA Topoisomerases (TOPs, TOP1 and TOP2) are mainstays of anti-cancer therapy. While they have proven effective, the toxicity of current TOP drugs caused by DNA damage-induced apoptosis of non-cancer cells, ...
Mechanisms of type 1 diabetic serum-induced hyperactivation of CaV1 channels in the pancreatic β cell
(2016-01-28)
The pancreatic β cell relies on appropriate Ca2+ entry through voltage-gated calcium (CaV)
channels to accomplish its unique function insulin secretion and to guarantee its viability.
Well-regulated β cell CaV channels ...