Search
Now showing items 1-8 of 8
Toll-like receptor-induced cytokine secretion by human monocytes in healthy donors and septic patients assessed at the single cell level
(2013-08-23)
Following the ligation of Toll-like receptors (TLRs) by bacterial-derived signature molecules, innate immune cells such as monocytes, macrophages and neutrophils initiate the inflammatory process by secreting chemokines ...
Antibodies as pathogenic factors and biomarkers in rheumatoid arthritis
(2021-05-21)
Ever since the evolution of an adaptive immune system capable of creating immune receptors that may recognize self-antigens, we have been at risk of autoimmunity. There are over 100 different types of autoimmune diseases ...
Characterisation of epitope-specific B cells and the role of IgG Fc sialylation in murine arthritis models
(2023-05-03)
Autoimmune diseases are a major burden for society and economy. One of the most common autoimmune diseases is rheumatoid arthritis (RA) characterized by joint inflammation, swelling and pain. If left untreated, it ultimately ...
Redox regulation of T cells in autoimmunity
(2021-09-03)
Autoimmune disorders affect a significant part of the population and therefore present a serious health and economic burden. One of the most common autoimmune diseases is rheumatoid arthritis (RA), affecting 0.5-1% of the ...
Identifying genetic determinants of T cell-dependent autoimmunity using forward genetics
(2021-07-29)
Rheumatoid arthritis (RA) affects 0.5-1% of the population and is an important health and socioeconomic problem. RA has a high degree of heritability. Thus, extensive efforts have been made to better understand the genetic ...
Functional studies of anti-gpi monoclonal antibodies and anti-citrullinated protein antibodies (ACPAS)
(2023-05-11)
RA is an autoimmune disease that primarily impacts joints throughout the body. The disease can result in pain, stiffness, and reduced mobility. It is a chronic disease, meaning that it lasts a long time and can worsen over ...
Psychological factors, sickness behavior and inflammatory biomarkers in longstanding pain
(2022-05-24)
Background: Longstanding pain affects a large number of adults worldwide. In addition to pain, several factors like depression, anxiety, and insomnia can also affect disability and quality of life. Some patients improve ...
Multimodal neuroimaging of pain and inflammation in the central nervous system in patients with fibromyalgia and rheumatoid arthritis
(2021-01-22)
The prevalence of concomitant fibromyalgia (FM) is puzzlingly high among rheumatoid arthritis (RA) patients and a contemporary challenge is to resolve why some RA patients continue to report pain despite adequate treatment ...