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Different approaches to develop radio- and chemotherapy for treatment of human cancer
(2014-09-03)
Despite huge advancements in our knowledge and understanding of the molecular mechanisms of carcinogenesis, the prognoses of many malignant diseases have not improved dramatically. Improvements in the therapeutic efficacy ...
Methods for studying memory B-cell immunity against malaria
(2020-05-15)
Plasmodium falciparum malaria remains one of the world’s deadliest infectious diseases and the search for an effective vaccine is highly warranted. Memory B cells (MBCs) and the antibodies they produce, once activated, is ...
Studies on gamma-secretase activity and products
(2010-02-26)
gamma-Secretase is a transmembrane aspartyl protease involved in processing of a multitude of functionally diverse substrates within their transmembrane domains. gamma-Secretase cleavage of the amyloid precursor protein ...
Notch signaling : from receptor cleavage to chromatin remodeling
(2005-10-28)
One of the principal signaling mechanisms that control development of multicellular organisms is the Notch signaling pathway. The transmembrane Notch receptor, presented at the cell surface, interacts with ligand on ...
Molecular studies of the γ-secretase complex : focus on genetic and pharmacological modulation
(2012-09-13)
γ-Secretase is a multi-subunit protease complex, composed of presenilin (PS1 or PS2), Nicastrin, Pen-2 and Aph-1, which generates the Alzheimer disease (AD) related 30-43 amino acid long amyloid β-peptide (Aβ). The complex ...