Search
Now showing items 1-10 of 15
The importance of nitric oxide availability in myocardial ischemia-reperfusion injury : regulatory roles of arginase, L-arginine and tetrahydrobiopterin
(2016-05-16)
Background. Maintenance of nitric oxide (NO) availability is crucial for cardiovascular homeostasis and protection against myocardial ischemia-reperfusion (IR) injury. The mechanisms underlying reduced NO availability are ...
Systems microscopy analysis of cell migration
(2015-11-18)
Single cell migration is heterogeneous and a complicated process. It arises from a hugely complex network of multi-scale interactions between molecular and macromolecular entities. Though the full, spatiotemporally resolved ...
Antimicrobial peptides and proteins in innate immunity : emphasis on isolation, characterization and gene regulation
(2005-03-18)
Antimicrobial peptides are endogenous antibiotics and effector molecules
of Innate immunity. These peptides are mainly localised to epithelial
linings and circulating neutrophils. They kill microbes by disruption of
their ...
Transcriptional regulation of neuronal differentiation in the developing CNS
(2017-02-02)
The central nervous system (CNS) is responsible for our intellectual and cognitive functions and it comprises the brain and spinal cord. Generation of the CNS occurs during embryonic development from the neural tube that ...
Diverse effects of endocrine-disruptive chemicals on Leydig and adrenocortical cell steroidogenesis in rodents and humans
(2017-09-22)
We are living in a man-made world and often exposed to different chemicals known as endocrine disrupting chemicals (EDCs) that negatively influence our hormonal system. These compounds have the potential to interrupt a ...
Bacterial gene expression inhibition with antisense peptide nucleic acids
(2005-05-12)
Regulated gene expression is widely useful for gene function studies and as a means to control genes important in disease. There are many methods for regulating the expression of genes, and one approach is to use antisense ...
Aspects on the modulation of potassium channels in insulin-producing beta-cells
(2006-10-27)
This thesis attempts to further clarify mechanisms behind the negative effects of overstimulation and the beneficial effect of β-cell rest. For this purpose diazoxide - opener of K+-ATP channels, which reversibly inhibits ...
Studies on new tuberculosis vaccine candidates in animal models
(2005-04-12)
Background: Tuberculosis (TB) is a major health problem in many countries, especially in low income countries. Globally, TB causes more than 2 million human deaths annually and 1/5 of all adult deaths in developing countries. ...
Chemokine receptor expression and function in experimental autoimmune neuroinflammation
(2007-05-25)
Neuroinflammatory lesions in the central nervous system (CNS) are characterized by the presence of leukocytes, mainly monocytes/macrophages, derived from the systemic compartment. We believe CC inflammatory chemokine ...
B-cell responses after pertussis vaccination
(2014-05-02)
Despite years of vaccination efforts, whooping cough, or pertussis, is not under control. Although immunization has greatly reduced the disease incidence, thousands of children die of whooping cough each year. Therefore, ...