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Targeting non-receptor tyrosine kinases using small molecule inhibitors : an overview of recent advances
(2015-12-28)
Protein tyrosine kinases are enzymes that catalyze the transfer of phosphate groups from ATP to tyrosine residues on other proteins as substrate. Phosphorylation at tyrosine residues regulates several functions, including ...
The role of angiopoietin-like 4 in inflammation
(2017-05-04)
Inflammation is a homeostatically fundamental feature of the host defence surveillance system made up of an army of sentinel cells that guard against foreign intrusion. At the onslaught of an attack, primary immune responders ...
Interindividual variation in drug metabolism with focus on polymorphic cytochrome P450 2C9
(2005-09-09)
Cytochromes P450 (CYP) are enzymes, mainly catalysing the oxidation of xenobiotics, in order to facilitate their excretion from the body. CYP2C9 is a polymorphic enzyme, which is responsible for the metabolism of about 10 ...