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Interindividual variation in drug metabolism with focus on polymorphic cytochrome P450 2C9
(2005-09-09)
Cytochromes P450 (CYP) are enzymes, mainly catalysing the oxidation of xenobiotics, in order to facilitate their excretion from the body. CYP2C9 is a polymorphic enzyme, which is responsible for the metabolism of about 10 ...
Dynamic protein trafficking of the nuclear membrane and peroxisomes
(2009-01-30)
The cell nucleus is enclosed by the nuclear envelope (NE), a double lipid membrane separating the nucleoplasm from the cytoplasm. Transport of macromolecules between the nucleus and the cytoplasm takes places through nuclear ...
Astrocytes in glioblastoma : enhancers of tumor growth, predictors of patient survival and potential therapeutic targets
(2020-02-18)
The tumor microenvironment plays an important role in glioblastoma, the most malignant primary brain tumor in adults. Astrocytes are a major component of the glioblastoma tumor microenvironment; therefore, their influence ...
Immunomodulation and its effector mechanisms in atherosclerosis
(2007-05-11)
Atherosclerosis is a disease of the arterial intima, characterized by
cholesterol deposition, inflammation and fibrosis. The pathogenesis of
atherosclerosis is related to both innate and adaptive immune responses,
and ...
Regulation of NK cell activity : studies of DAP12-associated receptors in immune synapse formation and in responses to cytomegalovirus infection
(2006-10-27)
Natural killer (NK) cell effector functions are important for innate resistance against tumor cells and viral infections. NK cells display a broad range of inhibitory and activating receptors on the cell surface, which ...
Vocational rehabilitation, work resumption and disability pension : a register-study of cases granted vocational rehabilitation by social insurance offices in a Swedish county
(2006-02-03)
Increasing figures for long-term sickness absence and disability pension are problems for many European countries where they have increased to burdensome levels, socially and financially. In a European study in 2003, Sweden ...
Genetic studies of candidate genes in eczema
(2008-01-11)
Eczema is a common inflammatory skin disorder characterised by itching and relapsing eczematous lesions. It usually presents in early childhood and affects about 10-20% of all children. The background is multifactorial, ...
Cardiovascular risk factors, brain structure, and cognitive decline in old age : a population-based study
(2015-08-21)
This doctoral thesis investigated the burden of cardiovascular risk factors among older adults (age ≥60 years) living in central Stockholm (Study I) and the associations of these risk factors with structural brain ...
Genetic analysis of ischemic stroke and predisposing carotid artery stenosis : a stroke carol
(2007-11-16)
Ischemic cerebrovascular disease (ICVD), consisting of ischemic stroke
and transient ischemic attacks (TIA), is a complex disease where
contribution from both the environment and genes promote pathogenesis of
the ...
Functional role of T-cell activation in viral hepatitis
(2009-02-13)
Hepatitis B and C (HBV, HCV) constitute global health problems and there are approximately 350 million chronically HBV infected people around the world, most of them are found in East and South East Asia and Africa. Worldwide ...