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Arthroplasty in patients with femoral neck fractures
(2011-05-03)
The aim of this thesis was to analyze hip function and the health-related quality of life (HRQoL) in patients with a displaced fracture of the femoral neck treated with a cemented total hip arthroplasty (THA) or a ...
K+ channels and the regulation of synaptic transmission
(2009-05-22)
Neuronal excitability is highly regulated by K+ channels that are activated by a voltage change across the plasma membrane or by a rise in intracellular Na+ or Ca2+ concentration. The main focus of this thesis has been to ...
Acute achilles tendon rupture : predictors and intervention to promote outcome
(2015-05-08)
Background: Orthopaedic trauma and surgery is still associated with major complications
related to immobilization, which results in reduced circulation, thromboembolic events,
impaired healing and functional deficits. ...
The many faces of IGF-1R from cell surface to the nucleus
(2009-05-01)
The IGF-1R is due to its implication in cancer an intensively studied subject of research. It is well known today that intracellular signals mediated by the IGF-1R play pivotal roles in tumorigenesis and cancer progression. ...
Biosynthesis of leukotriene B4 in hematological malignancies
(2005-05-27)
Leukotrienes (LT) are biologically active metabolites of the fatty acid
arachidonic acid (AA). After liberation of AA by phospholipase A 2 (PLA
2), this fatty acid can be converted to leukotrienes, lipoxins,
prostaglandins ...
On antidepressant effects of running and SSRI : focus on hippocampus and striatal dopamine pathways
(2007-05-25)
Considering the heterogeneous character of depression, it seems likely
that many brain regions are involved mediating the diverse symptoms of
depression. For example, the mesolimbic DA system has a central function
for ...
Protein expression in prostate cancer
(2006-01-06)
The molecular pathology of prostate cancer (PCa) is complex and the pathways and the acquired molecular defects responsible for PCa initiation, development and progression are still largely unknown. Tumors of the prostate ...
Long-term consequences of preterm birth : Swedish national cohort studies
(2011-05-06)
The World Health Organization defines preterm birth as birth before 37 complete weeks. The proportion of very preterm children with severe neurological disabilities has become smaller, but bulks of data indicate that, for ...
Tall stature : morbidity, mortality and treatment outcomes
(2016-01-15)
Tall stature is usually constitutional. In some cases excessive growth is caused by early puberty and in others by growth disorders such as Marfan syndrome or pituitary gigantism. Some individuals experience a substantial ...
The oncogenic role of histone chaperone ASF1 proteins in solid tumors
(2020-10-02)
Chromatin is the essential medium connecting regulatory signals such as transcription factors and signaling pathways to the alteration of gene activity and cellular phenotypes. Aberrant chromatin (epigenetic) environment ...