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Gene expression profiling in periodontitis
(2015-02-06)
The chronic inflammatory disease periodontitis is characterized by destruction of periodontal tissue, i.e. the tissues that surround and support the teeth. This complex disease is multifactorial, involving oral pathogens, ...
Tissue- and site-specific effects of PPARγ activation and its role in chronic inflammation
(2011-05-09)
Developmental programming, metabolism, immune function and tissue homeostasis in multicellular organisms are regulated by a plethora of stimuli. Transcription factors (TFs) convert incoming signals to appropriate transcriptional ...
The bioenergetic roles of PGC-1α1, kynurenines, and GPR35 in exercise and obesity
(2021-11-09)
Obesity is a major cause of medical comorbidity with detrimental effects on health span. Fundamentally, obesity is a condition of disrupted energy metabolism, where energy intake chronically exceeds expenditure. Over time, ...