Search
Now showing items 1-10 of 12
Assessment of frailty in old people with multimorbidity
(2023-11-02)
Background: As the population grows older, understanding and management of multimorbidity and frailty will
become increasingly important. There is no consensus on how to define or measure frailty and awareness of
frailty ...
Tissue- and site-specific effects of PPARγ activation and its role in chronic inflammation
(2011-05-09)
Developmental programming, metabolism, immune function and tissue homeostasis in multicellular organisms are regulated by a plethora of stimuli. Transcription factors (TFs) convert incoming signals to appropriate transcriptional ...
In silico prediction of CIS-regulatory elements
(2004-04-19)
As one of the most fundamental processes for all life forms, transcriptional regulation remains an intriguing and challenging subject for biomedical research. Experimental efforts towards understanding the regulation of ...
Influence of the microflora on gastrointestinal nitric oxide generation : studies in newborn infants and germ-free animals
(2006-05-11)
Interactions between intestinal bacteria and the host play an important role in physiological regulation of gut function and in development of various diseases. Nitric oxide (NO) exhibits a variety of biological actions ...
Genetics and biomarkers of frailty : towards individualized management of the frailty syndrome
(2023-10-09)
Frailty is an age-related, dynamic state of multisystem physiological decline and is a
strong predictor of disability and mortality. To move towards an individualized management
of frailty, a better understanding of its ...
Trends in population health in an era of increasing longevity
(2022-01-26)
In Sweden, the number of older adults over the age of 85 increased by 75% since 1990 while the number of centenarians has almost quadrupled. Rapid population ageing is a global phenomenon and projected to continue in almost ...
Sickness absence : subsequent psychiatric morbidity and suicidal behaviour
(2015-11-20)
Background: Sickness absence is a frequent recommendation in Swedish health care. Yet, research on future health outcomes of being sickness absent is sparse. Mental disorders are one of the most common diagnostic groups ...
The role of cyclin E in cell cycle regulation and genomic instability
(2004-04-23)
Cyclin E, a positive regulatory subunit of Cdk2, normally accumulates periodically at the G1/S transition, where it promotes entry into S phase and other DNA replication-associated functions. However, in many types of human ...
Combining mass spectrometric tissue imaging with conventional histology : focus on Alzheimer’s disease
(2012-02-24)
Historically, most scientific discoveries have been accompanied by previous technological innovation. Representative examples are the introduction of gene sequencing technologies, which allowed for the mapping of the human ...
Primary hyperparathyroidism : nonclassical symptoms and benefits from parathyroidectomy
(2021-09-28)
Primary hyperparathyroidism (PHPT) is characterized by an inadequate increase in calcium and parathyroid hormone levels in blood. The cause is usually a benign tumor, parathyroid adenoma, and the only curative treatment ...