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The role of PDGFB in dermatofibrosarcoma protuberans and giant cell fibroblastoma
(2000-02-18)
Dermatofibrosarcoma protuberans (DFSP) and giant cell fibroblastoma (GCF) are rare invasive tumors of the dermis. GCF is considered the juvenile form of DFSP. Both DFSP and GCF are characterized by the presence of chromosomal ...
Neuroimaging biomarkers in Alzheimer’s disease
(2017-05-11)
Alzheimer’s disease (AD) is characterized by an accumulation of abnormal plaques and tangles in the brain, a process that is estimated to begin years before the appearance of clinical symptoms. Individuals with subjective ...
Depression and cognition in the elderly : neuroimaging perspective
(2017-05-03)
This thesis examines the relationship between depression and brain structure in the elderly with (Study I, III) and without (Study II, IV) cognitive impairment (Alzheimer’s disease and mild cognitive impairment). Individuals ...
Roles of NUDT5 and NUDT15 beyond oxidized nucleotide sanitation and their potential as therapeutic targets
(2018-03-15)
The nucleotide precursor pool is readily susceptible to numerous sources of modification and damage, including alkylation, deamination and oxidation/nitrosylation, among others; most of which have deleterious effects on ...