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Roles of NUDT5 and NUDT15 beyond oxidized nucleotide sanitation and their potential as therapeutic targets
(2018-03-15)
The nucleotide precursor pool is readily susceptible to numerous sources of modification and damage, including alkylation, deamination and oxidation/nitrosylation, among others; most of which have deleterious effects on ...
Hypoxic ischemic encephalopathy : diagnosis, hypothermia treatment and outcome
(2010-04-30)
Hypothermia treatment (HT) is now proven to be neuroprotective, is
associated with favourable outcomes, and is considered as the standard of
care for moderate to severe hypoxic ischemic encephalopathy (HIE). The
treatment ...
Infection early in life and risk of non-affective psychosis
(2015-04-07)
In light of the increasing, but insufficient, evidence that various infections and immunological processes during brain development are associated with psychotic disorder, the aim of this thesis was to investigate infection ...
Human cytomegalovirus in congenital infections and embryonal malignancies of the nervous system
(2009-10-02)
Cytomegalovirus (CMV) is a herpesvirus that may cause severe or even fatal disease in immunocompromised patients as well as severe developmental disturbances in foetuses infected in utero. In contrast, only mild symptoms ...