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Metastatic bone disease
(2000-01-21)
Aim: To evaluate epidemiology, prognosis and diagnostics in metastatic bone disease and identify risk factors for failure after operation for pathologic fracture.
Patients: The study was based on patients treated ...
Regulation of mitochondrial gene expression in metazoa
(2013-08-12)
Mitochondria are essential organelles of eukaryotic cells and their main function is to provide the cell with the ubiquitously used energy currency ATP. Impaired energy conversion caused by mitochondrial dysfunction is a ...
Studies on syndecan-1 in mesenchymal tumors
(2010-01-08)
The syndecans are a four-member family of type I transmembrane proteoglycans. Their core proteins have a short cytoplasmic domain, a transmembrane domain and a large N-terminal extracellular domain possessing glycosaminoglycan ...
Mechanisms influencing natural killer cell recognition of tumour cells
(2016-04-12)
Natural killer (NK) cells are part of our innate immune defence against virus-infected and transformed cells. Through a yet undefined mechanism, expression of inhibitory receptors for self-HLA class I molecules endow NK ...
Eating habits among adolescents and their mothers : Stockholm Weight Development Study (SWEDES)
(2008-04-04)
The aims of this thesis were threefold. Firstly, to explore the possibility to improve the quality of dietary data and to identify under- and overreporters of energy intake. Secondly, to investigate the eating habits of ...
Regulation of Hedgehog signalling during development and carcinogenesis
(2009-11-26)
Hedgehog (Hh) signalling is one of the most important signalling networks in the body and, when miss-regulated, has been implicated in many human tumours, particularly that of skin (Basal Cell Carcinoma, BCC) and brain ...
Molecular studies of hypothalamic food intake regulating systems and central myelination in two anorectic mouse models
(2016-05-20)
The aim of this thesis is to increase the understanding of the hypothalamic mechanisms that are vital for food intake regulation, in particular as it relates to anorexia, and the molecular mechanisms underlying myelination ...
Nuclear receptor functions in the central nervous system : clues from knockout mice
(2006-02-10)
The nuclear receptor (NR) superfamily is the largest known family of transcription factors in eukaryotes. In the 1980 s when the size of the NR family and the scope of the functions of its members were being discovered, ...
Brain imaging and outcome in extremely preterm infants
(2011-04-08)
In parallel to the dawn of modern neonatal intensive care, the survival after extremely preterm birth has greatly improved. These very immature children are born during a vulnerable phase of brain maturation, and are at ...
Translational studies of syndecan-1 as angiogenesis inhibitor : from basic research to clinical applications
(2021-05-03)
Malignant mesothelioma (MM) is a highly aggressive primary tumor of the pleura, associated with poor prognosis. MM is mainly related to exposure to mineral fibers such as asbestos. The diagnosis of MM, despite multiple ...