Search
Now showing items 1-5 of 5
Molecular studies on Hirschsprung disease and 'Ondine's curse'
(1999-03-19)
This thesis is based on molecular studies of two diseases that arise from dysfunction of, defective migration or inappropriate apoptosis of neural crest derived cells: Hirschsprung disease (HSCR) and "Ondine's curse" ...
Regulation of human thioredoxin and glutaredoxin systems by oxidation and S-nitrosylation
(2008-03-21)
The homeostasis of intracellular redox status has a crucial role in the
cell survival and different processes such as DNA synthesis, gene
expression, enzymatic activity, etc. This homeostasis is achieved via an
intense ...
Mammalian thioredoxin reductase as a drug target in anticancer therapy through direct apoptosis induction by selenium compromised forms of the protein
(2006-05-12)
The mammalian thioredoxin system, consisting of thioredoxin(s), thioredoxin reductase(s) and NADPH, participates in the regulation of many important systems in a mammalian cell. The mammalian thioredoxin reductases (TrxR) ...
Organization of signaling networks during receptor-mediated membrane protein trafficking
(2008-04-04)
The mechanisms by which receptor signals are organized in a synergic/hierarchical manner in time and space during regulation of integral membrane protein traffic remain a present challenge. The aim of this study was to ...
Selective insulin signaling in the pancreatic beta-cell via the two insulin receptor isoforms
(2005-02-18)
Insulin exhibits pleiotropic effects that are tissue- as well as development-dependent. However, the mechanisms by which insulin gains selective effects are poorly understood. Selectivity in insulin signaling is currently ...