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Dietary heterocyclic amines and human cancer risk
(1998-03-12)
Heterocyclic amines formed in meat during cooking are multi-site animal carcinogens and form DNA adducts in human tissues, but their relevance to human carcinogenesis has yet to be determined. The aim of this thesis was ...
Cellular and molecular factors in the pathogenesis of systemic autoimmunity and comorbidities
(2019-05-02)
Sjögren’s syndrome (SS) and systemic lupus erythematosus (SLE) are systemic rheumatic autoimmune diseases having a major impact on patient’s wellbeing. Besides fatigue, pain and direct damage to exocrine glands in SS, and ...
PAK4 in organ development and cancer initiation
(2021-05-28)
Tumors are complex organs with a unique ecosystem containing tumor cells entangled with various infiltrating cells. Tumors have distinct signaling signatures, which confers upon it the ability to grow in the primary host ...
Famine in Nigeria and vitamin D in Sweden : two early life exposures and their relation to cardiovascular risk in adulthood
(2013-12-18)
Early life environment has in previous research been linked to risk of disease in adulthood. This thesis investigated three types of early life exposures and their potential associations with adult life cardiovascular risk. ...
PAK4 signaling in development and cancer
(2019-10-17)
Our understanding of cancer biology has been evolving rapidly shaped by groundbreaking discoveries. We now understand that cancer is not one disease but many, and that tumors are not foreign objects in the human body but ...
Retinal tumorigenesis and neurodegeneration : strategies to promote tumor cell death and support retinal cell survival to preserve vision
(2019-12-27)
Our vision is central to our quality of life enabling us to interact with our environment and lead productive lives. The ability to see begins in the retina, one of the paramount features of the eye, as it takes on the ...