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Neurotrophic factors and their receptors structure-function relationships and signalling mechanisms
(1997-04-04)
Background: The development, survival and maintenance of the vertebrate nervous system requires the continuous supply of a set of polypeptides termed neurotrophic factors. Among these, the neurotrophins (NTs) and members ...
Calcium signaling : molecular mechanisms and cellular consequences
(2008-11-21)
Cells exploit calcium (Ca2+) signaling to transmit information. In a
multicellular organism, each cell must be able recognize, process, and
respond to information received from the surrounding environment. In this
thesis ...
Injury prevention and safety promotion in rural communities : contribution of community health workers and an injury data registry system in Iran
(2009-05-18)
Injuries affecting people from the rural populations of middle-income
countries are poorly documented and so are people health care seeking
behaviour and their views and concern about injury prevention. The aim of
this ...
The secret life of nuclear IGF-1R : functions beyond traditional signaling pathways
(2014-09-26)
The implications of IGF-1R in normal development and disease are well established. IGF-1R plays pivotal roles in cell proliferation and cell survival and aberrant activation result in tumorigenesis and cancer progression. ...
Autonomic cardiac control in patients with epilepsy : spectral analysis of heart rate variability
(2006-11-03)
The heart is affected by the central nervous system via sympathetic and para-sympathetic efferents from autonomic centres in the brain stem. By assessing the beat to beat variation of the RR-intervals of the heart, i.e. ...
Studies on incretins and cardiovascular function
(2010-11-25)
Background: Type 2 diabetes (T2DM) is a strong risk factor for coronary heart disease (CHD). A great many diabetic subjects suffer from congestive heart failure (CHF), a condition with a high concomitant mortality. So far, ...
Medical decision-making capacity among geriatric patients with and without dementia : communication-based approaches for assessment and facilitation
(2019-03-07)
Introduction: Medical decision-making capacity concerns a patient’s cognitive abilities to make autonomous decisions regarding own person in medical contexts such as to choose treatment or accept/decline participation in ...
Early cardiovascular risk markers and cardiac function in children with chronic kidney disease
(2016-04-08)
Children with advanced chronic kidney disease (CKD) have an increased risk of premature death, foremost due to cardiovascular disease (CVD). The cardiovascular (CV) morbidity starts early in the disease process and renal ...