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Modulation of natural killer cell and T-cell functions by CD94/NKG2A receptors
(2006-08-21)
Natural Killer (NK) cells constitute a subset of lymphocytes capable of cytokine production and/or cellular cytotoxicity. Although NK cells can be activated experimentally by a multitude of agents, the in vivo mechanisms ...
Experimental combination therapy of brain cancer cell models
(2012-11-21)
Epigenetic alterations and aberrant expression of genes controlling epigenetic mechanisms have been identified in several cancers, including medulloblastoma and glioma, the most common primary brain tumors in children and ...
In vivo and in vitro studies of apolipoprotein CIII in diabetes
(2017-08-23)
Apolipoprotein CIII (apoCIII) is an important regulator of lipid metabolism and it is also known to have pro-inflammatory properties. From the point of view of diabetes it is interesting that both insulin deficiency and ...
The role of transcriptional repression in Shh signalling and patterning of the ventral neural tube
(2004-05-07)
From flies to humans, members of the Hedgehog (Hh) family of secreted signalling molecules play a vital role in determining cell fate and patterning during embryonic development. In vertebrates, Sonic Hedgehog (Shh) act ...
Etiology and early detection of nasopharyngeal carcinoma : an epidemiological approach
(2016-08-10)
Nasopharyngeal carcinoma (NPC) is a rare malignancy worldwide, but it is endemic in a few areas including southern China, Southeast Asia, North Africa, and the Arctic. The underlying mechanisms behind this remarkable ...
Immune monitoring in humans after manipulation by B cell depletion and immunization
(2007-01-12)
The overall goal of this thesis was to study the influence of
immunomodulatory drugs on the human immune system. The approach was
bi-directional; ex vivo studies were performed after B cell depletion
with rituximab treatment ...
Genetic mapping and association analysis in multiple sclerosis
(2005-01-14)
Multiple sclerosis (MS) is a chronic neurological disease. Epidemiological studies have shown evidence for both environmental and genetic involvement of the disease. The contribution of genes versus environment is complex, ...
Genetic variations influencing susceptibility to multiple sclerosis
(2005-11-11)
Multiple sclerosis (MS) is a chronic neurological disease affecting approximately 12 000 individuals in Sweden. Epidemiological studies have shown that most likely several genetic variations contribute and interact with ...
Optimization and validation of a species-specific in vivo approach for studies on growth and progression of neural crest derived tumours
(2010-05-07)
Background: Despite great advantages in cancer therapeutics during the last decades, therapy-resistance remains a problem in the majority of malignancies. Hence, development of more effective therapeutics is critical to ...
Analysis of global gene expression in complex biological systems using microarray technology
(2006-01-06)
The general aim of this thesis has been to explore the use of Affymetrix microarray technology in studies of global gene expression in complex biological systems, particularly with regard to the dynamics and heterogeneity ...