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Genetic variations influencing susceptibility to multiple sclerosis
(2005-11-11)
Multiple sclerosis (MS) is a chronic neurological disease affecting approximately 12 000 individuals in Sweden. Epidemiological studies have shown that most likely several genetic variations contribute and interact with ...
Epidemiological studies of the etiology of pancreatic cancer
(2008-01-11)
Pancreatic cancer is one of the most lethal human cancers with less than 5% of patients surviving 5 years. Despite an urgent need for primary prevention, little is known about the etiology of this cancer. This thesis was ...
Population and single-cell analysis of human cardiogenesis reveals unique LGR5 ventricular progenitors in embryonic outflow tract
(2021-02-15)
The morphogenetic process of mammalian cardiac development is complex and highly regulated spatiotemporally by multipotent cardiac stem/progenitor cells (CPCs). Mouse studies have been informative for understanding mammalian ...