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Bacterial virulence and adaptation mediated by two-component system signalling
(2006-05-25)
One of the most fundamental ways of signal perception and propagation is mediated by the bacterial two-component system (TCS). These types of systems mediate bacterial adaptation that may cause disease in a host due to ...
Helicobacter pylori eradication in the Swedish population
(2017-04-28)
Objectives: Helicobacter pylori (H. pylori) is associated with peptic ulcers and gastric cancer and its eradication aims to prevent these conditions. The recommended eradication regimen is triple therapy, consisting of a ...
Mechanisms and regulation of the polyphosphate/factor XII-driven contact system in thrombosis and hemostasis
(2016-10-03)
Blood coagulation leading to fibrin formation is essential to prevent loss of blood
(hemostasis), but can also contribute to occlusion of vessels (thrombosis). Thrombosis causes
pulmonary embolism, myocardial infarction ...
Mammalian thioredoxin reductase as a drug target in anticancer therapy through direct apoptosis induction by selenium compromised forms of the protein
(2006-05-12)
The mammalian thioredoxin system, consisting of thioredoxin(s), thioredoxin reductase(s) and NADPH, participates in the regulation of many important systems in a mammalian cell. The mammalian thioredoxin reductases (TrxR) ...
Neutrophil-induced endothelial barrier dysfunction in acute inflammation : mechanisms and therapeutic strategies
(2020-01-17)
The acute inflammatory response is characterized by recruitment of leukocytes and increased vascular permeability, resulting in the cardinal signs of inflammation; redness, heat, swelling, pain and loss of function. ...