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Macrophages : as central inflammatory mediators and as targets for therapeutic interventions
(2006-01-06)
Macrophages (Mphis) are important cellular players in autoimmune pathogenesis, being the most numerous cells infiltrating sites of inflammation and causing much of the associated tissue damage. Apart from these proinflammatory ...
Identification and characterization of stem Leydig cells in the testis
(2014-10-02)
In the testis, several cell types are needed to ensure male fertility, among them the testosterone-producing Leydig cells. Testosterone supports the maturation of sperm and maintains the male phenotype. Functional Leydig ...
Molecular mechanisms of cardiovascular calcification
(2019-05-23)
Cardiovascular calcification is a pathophysiological process characterized by the deposition of calcium-phosphate crystals in the arteries and the leaflets of the heart valves. In the arteries calcification causes arterial ...
Role of AKT/ PKB and 14-3-3 in the regulation of B cell receptor signaling and signalosome assembly
(2015-05-05)
AKT/PKB is an oncogenic serine/threonine kinase regulated via the PI3K pathways. 14-3-3s represent a large group of adaptor proteins that are known to interact with a plethora of signaling proteins and regulate diverse ...
Functional and genetic studies in type 2 diabetes and obesity
(2013-11-14)
Type 2 diabetes (T2D) and obesity are highly prevalent disorders reflecting a complex interplay of genetics, epigenetics, and environment. They constitute serious health problems and lead to significant morbidity and ...
Adenocarcinoma of the cervix uteri : methods to improve diagnostics : biological markers and HPV testing
(2013-11-06)
Cervical adenocarcinoma (ADC) represents about 20% of invasive cervical cancers. Implementation of screening programs that have led to a decrease in squamous cell carcinoma (SCC) has only had a limited preventive effect ...
Occurrence of human papillomaviruses (HPV) types in HPV related cancer and in the genital and oral tracts of young adults
(2012-08-24)
Human papillomavirus (HPV) is associated to cancer of the uterine cervix, the third most common
cancer among women, but also to head and neck squamous cell carcinoma (HNSCC), the sixth most
common type of cancer in the ...