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Synthesis of indoles, bisindoles and indolocarbazoles : high affinity aryl hydrocarbon receptor ligands
(2004-09-03)
This thesis deals with the synthesis and reactions of indoles,
bisindoles, indolocarbazoles and their derivatives. New methods for ring formation of planar, heterocyclic quinones, with the
indolo[3,2b]carbazole or ...
Studies in nuclear receptor Nurr1 : identification of Nurr1-regulated genes
(2004-04-27)
The nuclear receptor family comprises more than sixty members, including
receptors for steroids, thyroid hormone and retinoids. Many nuclear
receptors function as ligand- activated transcription factors that
regulate ...
Environmental risk factors for autism spectrum disorders
(2013-04-04)
Aims: Two overarching hypotheses were tested in this thesis- first, that the environmental factors studied during pregnancy or the time preceding birth would be associated with a higher risk of autism spectrum disorders ...
Some aspects of nuclear receptor function in the CNS : novel roles of Nurr1 and RXR in developing and mature neurons
(2002-09-13)
The nuclear receptor superfamily comprises the receptors for steroid hormones, thyroid hormone, vitamin D and retinoids. The family also includes a number of receptors that lack identified ligands, and are therefore referred ...
Nuclear receptor and Wnt function in developing dopaminergic neurons
(2007-01-26)
The progressive degeneration of dopaminergic neurons in the substantia
nigra is one of the major pathological events associated with Parkinson’s
Disease. Dopaminergic (DA) cell replacement therapy has emerged in recent
years ...
Diabetes mellitus, glucose abnormalities and acute coronary syndromes : studies on prevalence, risk and impact of treatment
(2003-05-23)
Background: Persons with diabetes mellitus and impaired glucose tolerance are at increased risk for cardiovascular disease.The prevalence of known diabetes among patients with acute myocardial infarction, about 20%, is ...
Wnt/beta-catenin signaling in midbrain dopaminergic neurons
(2006-04-07)
Parkinson's disease (PD) is caused by a progressive degeneration of the dopaminergic (DA) neurons of the substantia nigra. However, the mechanisms underlying the degeneration remain elusive and there is no cure for P1) at ...
Generation of dopamine neurons in vivo and from embryonic stem cells in vitro
(2009-03-06)
Mesencephalic dopamine (mesDA) neurons degenerate in patients with Parkinson s disease. In order to develop new treatment strategies for rescuing or replacing degenerating mesDA neurons, an improved understanding of the ...
The Wnt pathway in ventral midbrain dopaminergic differentiation
(2010-12-17)
Parkinson’s disease (PD) is a debilitating neurodegenerative disease in which dopaminergic (DA) neurons in the substantia nigra are lost. Current treatments such as administration of levodopa (L-DOPA) are initially effective ...
A study of the generation of diversity in the central nervous system
(2011-02-14)
Developmental biology is concerned with understanding the mechanisms that govern the generation of a whole organism starting from one single cell. In the central nervous system (CNS) the development of different classes ...