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Airway smooth muscle as a target in asthma : new insights into bronchorelaxation and hyperreactivity
(2015-05-08)
Patients with asthma suffer from reversible airway obstruction accompanied by airway hyperresponsiveness (AHR). Airway smooth muscle (ASM) is central to bronchoconstriction and AHR and is therefore the target of existing ...
Characterization of ERp29 : a novel secretion factor of endoplasmic reticulum
(2005-04-29)
ERp29 is a ubiquitously expressed endoplasmic reticulum protein strongly
conserved in mammalian species. The N-terminal domain of ERp29 is similar
to the thioredoxin domain of protein disulfide isomerase (PDI) lacking
however ...
To kill two birds with one stone : targeting myeloid cells in cancers
(2015-05-08)
Cancer progression is often accompanied by chronic inflammation and severe impairment of the immune system. In recent years, therapies eliciting tumor-specific immunity have resulted in striking tumor control and survival ...