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Studies of presenilin function in neurodegeneration and in human embryonic CNS during development
(2004-05-21)
Presenilin-1 (PS1) and -2 (PS2) gene mutations cause early onset familial
Alzheimer's disease (FAD). Presenilins provide gamma-secretase activity
for cleaving transmembrane proteins such as the amyloid precursor ...
Structural-functional studies of mitochondrial matrix proteins
(2018-11-01)
The mitochondrion is the powerhouse of the eukaryotic cell. Most of the energy required to carry out cellular processes is generated inside mitochondria via the process of oxidative phosphorylation. The machinery required ...
Detection and characterization of novel proteins in Trypanosoma cruzi
(2008-04-25)
Trypanosoma cruzi is a flagellated protozoan parasite. It infects a wide range of mammals, including humans. Human T. cruzi infections are endemic to South and Central America. The parasite is transmitted to humans mainly ...
Intrinsic and extrinsic mechanisms for B-cell lymphoma development and progression studied by global gene expression profiling
(2019-09-10)
Mantle cell lymphoma (MCL) is a rare hematopoietic malignancy characterized by frequent relapses and poor survival, partly due to minimal residual disease, whereby a subset of malignant cells, harbored in protective niches, ...
Role of p21-activated kinase 4 in cell migration
(2010-11-30)
Cell migration is a cellular process that plays a critical role in various physiological and pathological phenomena, including in cancer metastasis. Understanding at a fundamental level how cancer cells migrate and invade ...
Uncemented femoral stems : studies on periprosthetic bone remodelling and prevention of bone loss in total hip arthroplasty
(2010-12-02)
Introduction: Tapered uncemented femoral stems are popular implants in total hip arthroplasty (THA). They are easy to use and excellent long-term results have been reported for patients with primary osteoarthritis of the ...