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Krävande beteenden i samband med demens : förekomst och olika förhållningssätt
(2004-05-21)
This thesis based on five studies conducted within community care sought
to I) study demanding symptoms and behaviour in persons > 65 years in
home care or sheltered housing and work load from a staff perspective
over ...
On angiogenesis modulation
(2009-08-28)
During evolution, the transition from unicellular to multicellular organisms required the origin of a transport system capable of interconnecting specialized cells throughout the body of the organism. In higher animals, ...
Structural basis of cysteine biosynthesis and peptidoglycan remodelling in Mycobacterium tuberculosis
(2013-12-12)
Mycobacterium tuberculosis is the causative agent of tuberculosis, which is responsible for 1.3 million deaths annually. Treatment is difficult due to an elaborate defense machinery, which includes specific metabolic changes ...
Cell wall remodeling proteins in Mycobacterium tuberculosis : structure, function and inhibition
(2017-10-27)
The complex and peculiar cell wall architecture is vital for the survival of M. tuberculosis in the host and therefore an established target for several currently used drugs. Understanding of the cell wall maintenance and ...
PTEN and Akt signalling in Alzheimer’s disease
(2005-11-18)
Akt / protein kinase B is an important cell survival kinase that modulates the activity of a range of pro-apoptotic proteins. A major downstream target of Akt is glycogen synthase kinase-3beta (GSK3beta) that phosphorylates ...
Stretching the genetic code : incorporation of selenocysteine at specific UGA codons in recombinant proteins produced in Escherichia coli
(2008-11-07)
Selenocysteine (Sec) exists in all domains of life and represents the
21st naturally occurring amino acid. A Sec residue is co-translationally
incorporated at a predefined opal (UGA) codon. UGA codons normally encode
for ...
Common viruses and host gene interactions in multiple sclerosis
(2013-03-19)
Multiple sclerosis (MS) is a neurological disorder, characterised by demyelination and inflammation of the central nervous system, leading to sensory and motor symptoms. MS is thought to be complex disease, with both ...
A 10-year follow-up of people with multiple sclerosis-aspects of disability and health, use of and satisfaction with care, and feasibility of cognitive behavioural therapy
(2014-11-21)
Background: Multiple sclerosis (MS) is a neuroinflammatory and neurodegenerative disease in the central nervous system which affects a number of life areas of the afflicted individual. Detailed knowledge is required on ...
Establishment and applications of a multiple sclerosis biobank : analysis of biomarkers and therapeutic complications in MS
(2010-02-05)
Biomarkers for disease activity and prognosis in multiple sclerosis (MS)
are lacking. We established a MS biobank consisting of paired
cerebrospinal fluid samples (CSF) and peripheral blood samples from MS
patients and ...
Diabetes pathogenesis : role of natural killer cells, T cells and a novel neuropeptide
(2010-05-28)
Diabetes is a major health problem affecting nearly 5% of the population
world wide. It is a heterogeneous group of diseases with the autoimmune
type 1 diabetes (T1D) and the metabolic type 2 diabetes (T2D) being the
major ...