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Clinical, histopathologic and genetic diagnosis in osteogenesis imperfecta and dentinogenesis imperfecta
(2004-01-23)
The aims of this thesis were to investigate (1) dental aberrations in a large sample of unrelated patients with different types and forms of OI, (2) degree of dentin dysplasia in relation to type and form of OI and clinical, ...
X-chromosome upregulation is driven by increased burst frequency
(2020-05-12)
Ohno's hypothesis postulates that X-chromosome upregulation rectifies X-dose imbalance relative to autosomal genes, present in two active copies per cell. Here we dissected X-upregulation into kinetics of transcription, ...
Somatostatin effects on the proteome of human prostate cancer cells
(2009-01-09)
The transition of prostate cancer from androgen dependent to the therapy resistant androgen independent state, is a large and persistent problem in the clinical management of prostate cancer.
The aim of this thesis ...
Suicide and mortality related to mental disorder in three Swedish cohorts
(2010-04-02)
Aims: The subject of this thesis is suicide and other premature death related
to mental disorder. The overall aim is to provide knowledge to improve
prevention strategies. The specific aims are as follows: Study I: ...
Molecular regulation and analysis of neural stem and cancer cell characteristics
(2012-05-25)
Every single cell within an organism is constantly facing the demanding task of preserving the integrity of its genomic material to secure proper function and clearance from disease. To accomplish this cells rely on DNA ...
Adenosine receptors and stress : studies using methylmercury, caffeine and hypoxia
(2008-02-21)
Brain development is a precisely organized process that can be disturbed by various stress factors present in the diet (e.g. exposure to xenobiotics) as well as insults such as decreased oxygen supply. The consequent adverse ...
Attention deficit hyperactivity disorder in prison inmates
(2012-05-04)
Background: Attention deficit hyperactivity disorder (ADHD) is an inherited developmental disorder with early onset, chronically persisting in the vast majority of cases. ADHD is associated with pervasive cognitive, emotional ...
Mediators of synaptic activity in anxiety- and depression-related behaviors
(2012-05-16)
Depression and anxiety are leading causes of years lost to disability, despite antidepressants being among the most commonly prescribed medications. Most currently prescribed antidepressants were found serendipitously ...