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Differential expression pattern of CEACAM1 isoforms in polarized epithelial cells : it's regulation and some functional consequences
(2004-01-16)
The cell adhesion molecule CEACAM1 is expressed in epithelia, small
vessel endothelia and leukocytes as two major, co-expressed isoforms,
CEACAM1-L and CEACAM1-S, which differ in their cytoplasmic domains.
CEACAM1 has ...
Mechanisms influencing natural killer cell recognition of tumour cells
(2016-04-12)
Natural killer (NK) cells are part of our innate immune defence against virus-infected and transformed cells. Through a yet undefined mechanism, expression of inhibitory receptors for self-HLA class I molecules endow NK ...
The fibrinolytic enzyme system : new markers of potential interest in cardiovascular disease
(2005-12-30)
Impaired fibrinolytic function, mainly due to elevated plasma levels of PAI-1, is a common finding in patients with coronary heart disease. Determination or evaluation of the plasma PAI-1 concentrations are complicated, ...
Decoding the tumor microenvironment : a B-cell and macrophage perspective
(2019-05-02)
The immune system plays a role in many different functions in our body, and disease is no exception. Cancer is one of the biggest challenges of the twenty first century and vast efforts have been made to understand this ...
Health outcomes of women with breast cancer
(2014-12-17)
The overall survival of breast cancer patients has increased quite remarkably in the past decades in the developed countries due to substantial improvements in diagnosis and treatment. As a consequence, the proportion of ...
Nitric oxide in exhaled gas : studies on physiological regulation and measurements in infants and children
(1999-09-16)
Nitric oxide (NO) is found in the exhaled gas of humans, starting from birth, and is increased in adult patients with bronchial asthma. This study assessed whether the measurement of NO in exhaled gas is technically feasible ...
Robot-assisted laparoscopy and sentinel node biopsy in high risk endometrial cancer
(2018-11-15)
Surgery is standard treatment for early stage endometrial cancer (EC), the most common gynaecological malignancy in developed countries. Traditionally, surgery has been performed by laparotomy (LT). Comprehensive surgical ...
Studies on the role of SOCS3 and STAT3 in development and function of the immune system
(2017-11-27)
The immune system is composed of an innate and an adaptive response that protects us from the microbial attacks. The innate system provides a fast defense against infection. However, many microbes evade or overwhelm the ...
Shedding light on the STAT3 small molecule inhibitor field
(2019-05-13)
STAT3 is one of the seven family members of the STAT transcription factor family. STAT3 has become a very attractive target for cancer therapy and other diseases. It has a prominent role in cancer development as well as ...
Evaluation of function in individuals with knee osteoarthritis
(2017-09-27)
Introduction: Osteoarthritis, the most common joint disease, results in joint pain and limited function. In clinical practice, the array of measurements used to evaluate function are generally restricted to patient-reported ...