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Genetic differences in neuropathy and opioid responses in rats
(2003-11-28)
The studies examined mechanisms and treatments of experimental neuropathic pain with particular emphasis on the differences between rat strains and sub-strains in basal nociceptive sensitivity, development of neuropathic ...
Modulation of nuclear receptor function by interacting proteins
(2007-08-21)
Nuclear receptors are a family of transcription factors involved in many
biological processes. They represent key potentials as therapeutic
targets for several clinical conditions such as diabetes, obesity,
cardiovascular ...
Studies on molecular properties and functional regulation of terminal leukotriene C4 synthases and cysteinyl-leukotriene receptor signalling in human endothelium
(2007-03-09)
The transformation of the unstable intermediate leukotriene (LT) A4 into
the glutathione conjugate LTC4, the parent compound of LTD4 and LTE4, is
catalysed by leukotriene C4 synthase (LTC4S) as well as microsomal
glutathione ...
Glucose-lowering interventions and risk assessment in patients with coronary heart disease and disturbed glucose metabolism
(2012-03-21)
Background: Abnormal glucose regulation (AGR) including impaired glucose tolerance (IGT) and diabetes mellitus type 2 (T2DM) are common in patients with stable and unstable coronary artery disease (CAD) and impair their ...
Hypersexual disorder : clinical presentation and treatment
(2019-09-27)
Background: Persistent hypersexual behavior (HB) leading to negative consequences is a phenomenon that has lacked a recognized diagnosis in the psychiatric nomenclature, despite extensive study. Due to differences in the ...
Parents who have lost a son or daughter through suicide : towards improved care and restored psychological health
(2013-12-19)
Background: Parents that have lost a son or daughter through suicide are at risk of developing psychological morbidity that may become long-lasting and even life-threatening. Despite this the aftermath of a suicidal loss ...